Pub. Date : 2020 Mar
PMID : 32160269
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We used C57BL/6 (WT) and a gp91PHOX knockout mice (PHOX-/-), lacking functional NOX2, to investigate the effects of ablation of NOX2-derived ROS production on the outcome of acute chagasic cardiomyopathy. | Reactive Oxygen Species | cytochrome b-245, beta polypeptide | Mus musculus |
2 | Overall our data show for the first time that lack of NOX2-derived ROS promoted a pro-arrhythmic phenotype in the heart, in which the crosstalk between ROS and NO could play an important role in regulating cardiomyocyte electro-mechanical function during acute CD. | Reactive Oxygen Species | cytochrome b-245, beta polypeptide | Mus musculus |
3 | Overall our data show for the first time that lack of NOX2-derived ROS promoted a pro-arrhythmic phenotype in the heart, in which the crosstalk between ROS and NO could play an important role in regulating cardiomyocyte electro-mechanical function during acute CD. | Reactive Oxygen Species | cytochrome b-245, beta polypeptide | Mus musculus |
4 | Future studies designed to evaluate the potential role of NOX2-derived ROS in the chronic phase of CD could open new and more specific therapeutic strategies to treat CD and prevent deaths due to heart complications. | Reactive Oxygen Species | cytochrome b-245, beta polypeptide | Mus musculus |