Title : Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental Chagas disease.

Pub. Date : 2020 Mar

PMID : 32160269






4 Functional Relationships(s)
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1 We used C57BL/6 (WT) and a gp91PHOX knockout mice (PHOX-/-), lacking functional NOX2, to investigate the effects of ablation of NOX2-derived ROS production on the outcome of acute chagasic cardiomyopathy. Reactive Oxygen Species cytochrome b-245, beta polypeptide Mus musculus
2 Overall our data show for the first time that lack of NOX2-derived ROS promoted a pro-arrhythmic phenotype in the heart, in which the crosstalk between ROS and NO could play an important role in regulating cardiomyocyte electro-mechanical function during acute CD. Reactive Oxygen Species cytochrome b-245, beta polypeptide Mus musculus
3 Overall our data show for the first time that lack of NOX2-derived ROS promoted a pro-arrhythmic phenotype in the heart, in which the crosstalk between ROS and NO could play an important role in regulating cardiomyocyte electro-mechanical function during acute CD. Reactive Oxygen Species cytochrome b-245, beta polypeptide Mus musculus
4 Future studies designed to evaluate the potential role of NOX2-derived ROS in the chronic phase of CD could open new and more specific therapeutic strategies to treat CD and prevent deaths due to heart complications. Reactive Oxygen Species cytochrome b-245, beta polypeptide Mus musculus