Title : PTH/PTHrP Receptor Signaling Restricts Arterial Fibrosis in Diabetic LDLR-/- Mice by Inhibiting Myocardin-Related Transcription Factor Relays.

Pub. Date : 2020 May 8

PMID : 32160132






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Upregulation of Col3a1 and Col1a1 in PTH1R-VKO VSM was inhibited by small interfering RNA targeting Mkl1 and by treatment with the Mkl-1 antagonist CCG1423 or the Rock (Rho-associated coiled-coil containing protein kinase)-2 inhibitor KD025. CCG 1423 parathyroid hormone 1 receptor Mus musculus
2 VSM C1r protein and C1r message were increased with PTH1R deficiency, mediated by Mkl-1-dependent transcription and inhibited by CCG1423 or KD025. CCG 1423 parathyroid hormone 1 receptor Mus musculus