Title : Construction of redox-responsive tumor targeted cisplatin nano-delivery system for effective cancer chemotherapy.

Pub. Date : 2020 Apr 30

PMID : 32151664






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1 Herein, a tumor targeted and stimuli responsive nano-delivery system for cisplatin was constructed using branched polyethyleneimine (BPEI) as the backbone, disulfide bond as the redox-responsive covalent linker and hyaluronic acid (HA) as targeting recognition unit which can bind selectively to the receptor of CD44, which is highly expressed on the A549 tumor cells. Cisplatin CD44 molecule (Indian blood group) Homo sapiens