Title : Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin.

Pub. Date : 2020 Jun

PMID : 32145585

1 Functional Relationships(s)
Compound Name
Protein Name
1 Our results showed that Dox-induced damage in HUVECs were reduced through Kae to promote the expression of total protein 14-3-3gamma and mitochondrial Bcl-2, phosphorylate Bad, increase cell viability, NO content, DDAHIIactivity, p-eNOS/eNOS ratio, and MMP levels, maintained NAD+/NADH and GSH/GSSG balance, and decrease LDH and caspase-3 activities, ADMA content, ROS generation, mPTP openness, and apoptosis. Doxorubicin caspase 3 Homo sapiens