Pub. Date : 2020 May
PMID : 32144825
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Our results indicate that the L472P change present in NPC1 WT-V compromises NPC1 functionality in lysosomal cholesterol export. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
2 | Our results indicate that the L472P change present in NPC1 WT-V compromises NPC1 functionality in lysosomal cholesterol export. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
3 | All-atom molecular dynamics simulations suggest that the L472P change alters the relative position of the NPC1 middle and the C-terminal luminal domains, disrupting the recently characterized cholesterol efflux tunnel. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |