Title : Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells.

Pub. Date : 2020 Feb 24

PMID : 32106059

1 Functional Relationships(s)
Compound Name
Protein Name
1 rSLURP-1 fully abolished the nicotine-induced increase of the cell proliferation, down-regulation of the expression of PTEN (the negative regulator of the AKT pathway, controlling the growth, survival, and proliferation of cancer cells), and up-regulation of the alpha7-nAChR expression in the A549 cells. Nicotine AKT serine/threonine kinase 1 Homo sapiens