Pub. Date : 2020 Apr 1
PMID : 32101030
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |
| 2 | We found that whole body deletion of RIPK2 prevented the glucose-lowering effects of repeated NOD2 activation that were evident during a glucose tolerance test (GTT) in high-fat diet (HFD)-fed wild-type (WT) mice. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |
| 3 | We found that whole body deletion of RIPK2 prevented the glucose-lowering effects of repeated NOD2 activation that were evident during a glucose tolerance test (GTT) in high-fat diet (HFD)-fed wild-type (WT) mice. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |
| 4 | NOD2 activation lowered glucose during a GTT and lowered adipose tissue inflammation in mice with RIPK2 deleted in hematopoietic cells. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |
| 5 | We conclude that RIPK2 in nonhematopoietic cells mediates the glucose lowering and anti-inflammatory effects of NOD2-activating postbiotics. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |