Title : Na+/K+-ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives.

Pub. Date : 2020 Mar 27

PMID : 32096998






1 Functional Relationships(s)
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1 A preliminary structure-activity relationship investigation conducted indicated that the C-12 and C-14 hydroxy groups and the C-17 unsaturated lactone unit are important for 1 to mediate its cytotoxicity toward human cancer cells, but the C-3 glycosyl residue seems to be less critical for such an effect. unsaturated lactone cytokine like 1 Homo sapiens