Title : Lysosomotropic drugs enhance pro-inflammatory responses to IL-1β in macrophages by inhibiting internalization of the IL-1 receptor.

Pub. Date : 2020 May

PMID : 32088265






1 Functional Relationships(s)
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1 Chloroquine and hydroxychloroquine increased IL-1beta-induced CXCL8 secretion in macrophages which was critically dependent on the lysosomotropic character and inhibition of macroautophagy but independent from the NLRP3 inflammasome. Chloroquine NLR family pyrin domain containing 3 Homo sapiens