Pub. Date : 2020 May 1
PMID : 32088216
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. | Calcium | stromal interaction molecule 1 | Homo sapiens |
| 2 | Additional studies showed that melatonin elevated cytosolic calcium levels by upregulation of STIM1, leading to osteoblast apoptosis via the mitochondrial pathway. | Calcium | stromal interaction molecule 1 | Homo sapiens |
| 3 | Finally, we demonstrated that the STIM1-mediated increase in cytosolic calcium levels induced apoptosis through the ERK pathway. | Calcium | stromal interaction molecule 1 | Homo sapiens |
| 4 | SIGNIFICANCE: Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. | Calcium | stromal interaction molecule 1 | Homo sapiens |