Pub. Date : 2021 Feb 22
PMID : 32077934
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS: The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca2+ release to trigger cardiomyocyte contraction, participates in development of acquired and inherited arrhythmogenic cardiac disease. | Calcium | ryanodine receptor 2 | Homo sapiens |
| 2 | We also show that the RyR2 N-terminus domain interacts with the C-terminal channel pore region in a Ca2+-independent manner. | Calcium | ryanodine receptor 2 | Homo sapiens |
| 3 | Therapeutic strategies currently focus on gain-of-function RyR2 channels to suppress sarcoplasmic reticulum Ca2+ release either indirectly with class I/II anti-arrhythmic drugs, or by directly targeting RyR2 to inhibit channel activity. | Calcium | ryanodine receptor 2 | Homo sapiens |