Title : The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine.

Pub. Date : 2020 Feb 18

PMID : 32070304






3 Functional Relationships(s)
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1 The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 CONCLUSIONS: We suggest that the UGT1A4 rs2011425 polymorphism affects olanzapine tolerability because it is associated with the observed side effects of olanzapine in schizophrenia patients, namely sympathetic dysfunction. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
3 CONCLUSIONS: We suggest that the UGT1A4 rs2011425 polymorphism affects olanzapine tolerability because it is associated with the observed side effects of olanzapine in schizophrenia patients, namely sympathetic dysfunction. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens