Title : Differential kidney proximal tubule cell responses to protein overload by albumin and its ligands.

Pub. Date : 2020 Mar 1

PMID : 32068462

2 Functional Relationships(s)
Compound Name
Protein Name
1 Fatty acids and other ligands bound to albumin are known to trigger production of reactive oxygen species (ROS) that impair PT function. Fatty Acids albumin Homo sapiens
2 Whereas overnight incubation with high concentrations of fatty acid-free albumin had no overt effects on cell function or viability, lysosomal degradation kinetics were slowed upon longer exposure, consistent with overload of the PT endocytic/degradative pathway. Fatty Acids albumin Homo sapiens