Title : Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt/ERK/AMPK signaling pathway.

Pub. Date : 2020 Jun

PMID : 32061800






1 Functional Relationships(s)
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1 The present study demonstrated that the mitochondria-dependent apoptosis pathway was involved in Cr(VI)-induced SH-SY5Y cell (the human neuroblastoma cell line) death, which was accompanied by the appearance of cell shrinkage, increased mitochondrial membrane potential (MMP) depolarization, increased cytochrome c release, and the activation of caspase cascades and poly (ADP-ribose) polymerase (PARP). chromium hexavalent ion cytochrome c, somatic Homo sapiens