Title : Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction.

Pub. Date : 2020 Jul

PMID : 32054994






1 Functional Relationships(s)
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1 Enhanced expression of TNF and the activation of NLRP3 and CASP1 followed by the increased generation of IL-1beta and nuclear translocation of the NF-kappabeta transcription factor occurred in response to hemoglobin-derived peptides, and ferryl hemoglobin in endothelium was upregulated in both pathologies. ferryl iron NLR family pyrin domain containing 3 Homo sapiens