Title : Application of N-palmitoyl-O-phosphocholineserine for diagnosis and assessment of response to treatment in Niemann-Pick type C disease.

Pub. Date : 2020 Apr

PMID : 32033912






6 Functional Relationships(s)
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1 The most abundant species in this class of lipid, N-palmitoyl-O-phosphocholineserine (PPCS), was evaluated for diagnosis of NPC disease and treatment efficacy assessment with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) in NPC. 2-hydroxypropyl-beta-cyclodextrin phosphopantothenoylcysteine synthetase Homo sapiens
2 The most abundant species in this class of lipid, N-palmitoyl-O-phosphocholineserine (PPCS), was evaluated for diagnosis of NPC disease and treatment efficacy assessment with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) in NPC. 2-hydroxypropyl-beta-cyclodextrin phosphopantothenoylcysteine synthetase Homo sapiens
3 The most abundant species in this class of lipid, N-palmitoyl-O-phosphocholineserine (PPCS), was evaluated for diagnosis of NPC disease and treatment efficacy assessment with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) in NPC. 2-hydroxypropyl-beta-cyclodextrin phosphopantothenoylcysteine synthetase Homo sapiens
4 The most abundant species in this class of lipid, N-palmitoyl-O-phosphocholineserine (PPCS), was evaluated for diagnosis of NPC disease and treatment efficacy assessment with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) in NPC. 2-hydroxypropyl-beta-cyclodextrin phosphopantothenoylcysteine synthetase Homo sapiens
5 In an intravenous (IV) HPbetaCD trial, plasma PPCS in all patients was significantly reduced. 2-hydroxypropyl-beta-cyclodextrin phosphopantothenoylcysteine synthetase Homo sapiens
6 These results demonstrate that plasma PPCS was able to diagnose NPC1 patients with high sensitivity and specificity, and to evaluate the peripheral treatment efficacy of IV HPbetaCD treatment. 2-hydroxypropyl-beta-cyclodextrin phosphopantothenoylcysteine synthetase Homo sapiens