Title : Suppression of DRP1‑mediated mitophagy increases the apoptosis of hepatocellular carcinoma cells in the setting of chemotherapy.

Pub. Date : 2020 Mar

PMID : 32020220






1 Functional Relationships(s)
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1 Mechanistically, Mdivi-1 upregulated Bax and downregulated Bcl-xL, leading to an increase in mitochondrial membrane permeability and subsequent release of cytochrome c from mitochondria into the cytosol, thereby aggravating cisplatin-induced apoptosis in HCC cells. Cisplatin cytochrome c, somatic Homo sapiens