Pub. Date : 2020 Mar 27
PMID : 32019865
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rational design, synthesis and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | On the basis of X-ray structures of a CNS-penetrating reactivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)-inhibited human AChE (hAChE), here we created seven uncharged acetamido bis-oximes as candidate antidotes. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |