Pub. Date : 2020 May
PMID : 32018221
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-130a alleviated high-glucose induced retinal pigment epithelium (RPE) death by modulating TNF-alpha/SOD1/ROS cascade mediated pyroptosis. | Glucose | tumor necrosis factor | Homo sapiens |
| 2 | In addition, high-glucose (50 mM) significantly decreased the levels of miR-130a and superoxide dismutase (SOD) 1, and promoted tumor necrosis factor (TNF)-alpha expressions in ARPE-19 cells. | Glucose | tumor necrosis factor | Homo sapiens |
| 3 | Furthermore, overexpression of miR-130a abrogated the effects of high-glucose (50 mM) on the above cell functions, which were all reversed by either upregulating TNF-alpha or knocking down SOD1 in ARPE-19 cells. | Glucose | tumor necrosis factor | Homo sapiens |
| 4 | Taken together, upregulation of miR-130a alleviated the cytotoxic effects of high-glucose (50 mM) on ARPE-19 cells by regulating TNF-alpha/SOD1/ROS axis mediated pyroptotic cell death. | Glucose | tumor necrosis factor | Homo sapiens |