Title : Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor.

Pub. Date : 2020 Mar

PMID : 32018210






4 Functional Relationships(s)
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1 Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor. picroside II nuclear receptor subfamily 1, group H, member 4 Mus musculus
2 siRNA, Dual-luciferase reporter, quantitative real-time PCR and Western blot assay were used to demonstrate the farnesoid X receptor (FXR) pathway in the anti-cholestasis effects of picroside II in vivo and in vitro. picroside II nuclear receptor subfamily 1, group H, member 4 Mus musculus
3 siRNA, Dual-luciferase reporter, quantitative real-time PCR and Western blot assay were used to demonstrate the farnesoid X receptor (FXR) pathway in the anti-cholestasis effects of picroside II in vivo and in vitro. picroside II nuclear receptor subfamily 1, group H, member 4 Mus musculus
4 In addition, expression of FXR and the target gene Bsep was increased, whereas aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor alpha (PPARalpha) and their corresponding target genes were not significantly influenced by picroside II under cholestatic conditions. picroside II nuclear receptor subfamily 1, group H, member 4 Mus musculus