Pub. Date : 2020 Mar
PMID : 32018210
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor. | picroside II | nuclear receptor subfamily 1, group H, member 4 | Mus musculus | ||
2 | siRNA, Dual-luciferase reporter, quantitative real-time PCR and Western blot assay were used to demonstrate the farnesoid X receptor (FXR) pathway in the anti-cholestasis effects of picroside II in vivo and in vitro. | picroside II | nuclear receptor subfamily 1, group H, member 4 | Mus musculus | ||
3 | siRNA, Dual-luciferase reporter, quantitative real-time PCR and Western blot assay were used to demonstrate the farnesoid X receptor (FXR) pathway in the anti-cholestasis effects of picroside II in vivo and in vitro. | picroside II | nuclear receptor subfamily 1, group H, member 4 | Mus musculus | ||
4 | In addition, expression of FXR and the target gene Bsep was increased, whereas aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor alpha (PPARalpha) and their corresponding target genes were not significantly influenced by picroside II under cholestatic conditions. | picroside II | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |