Title : Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1.

Pub. Date : 2020 Apr

PMID : 32012403






1 Functional Relationships(s)
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1 We have previously shown that Ror2 receptor tyrosine kinase and its ligand, Wnt5a, are expressed in MSCs, and Wnt5a-Ror2 signaling in MSCs induces expression of CXCL16, which in turn promotes proliferation of co-cultured MKN45 gastric cancer cells via CXCL16-CXCR6 axis. Tyrosine receptor tyrosine kinase like orphan receptor 2 Homo sapiens