Title : Cation-chloride cotransporters and the polarity of GABA signalling in mouse hippocampal parvalbumin interneurons.

Pub. Date : 2020 May

PMID : 32012273






2 Functional Relationships(s)
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1 ABSTRACT: Transmembrane chloride gradients govern the efficacy and polarity of GABA signalling in neurons and are usually maintained by the activity of cation chloride cotransporters, such as KCC2 and NKCC1. gamma-Aminobutyric Acid solute carrier family 12, member 2 Mus musculus
2 Focal GABA uncaging in whole-cell recordings reveal that KCC2 and NKCC1 are functional in both PV INs and PCs but differentially contribute to transmembrane chloride gradients in their soma and dendrites. gamma-Aminobutyric Acid solute carrier family 12, member 2 Mus musculus