Pub. Date : 2020 Jan
PMID : 32010792
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the current clinical boron neutron capture therapy (BNCT), p-boronophenylalanine (BPA) has been the most powerful drug owing to its ability to accumulate selectively within cancers through cancer-related amino acid transporters including LAT1. | 4-boronophenylalanine | solute carrier family 7 member 5 | Homo sapiens |
| 2 | In the current clinical boron neutron capture therapy (BNCT), p-boronophenylalanine (BPA) has been the most powerful drug owing to its ability to accumulate selectively within cancers through cancer-related amino acid transporters including LAT1. | 4-boronophenylalanine | solute carrier family 7 member 5 | Homo sapiens |
| 3 | Here, we report that poly(vinyl alcohol) (PVA) can form complexes with BPA through reversible boronate esters in aqueous solution, and the complex termed PVA-BPA can be internalized into cancer cells through LAT1-mediated endocytosis, thereby enhancing cellular uptake and slowing the untoward efflux. | 4-boronophenylalanine | solute carrier family 7 member 5 | Homo sapiens |