Title : CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.

Pub. Date : 2020 May

PMID : 32007561






2 Functional Relationships(s)
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1 Docking of 11OHP4, 11KP4 and the 5alpha-reduced metabolites, 5alpha-pregnan-11beta-ol-3,20-dione (11OH-DHP4) and 5alpha-pregnan-3,11,20-trione (11K-DHP4) with human CYP17A1 showed minimal changes in the orientation of these C11-oxy C21 steroids in the active pocket when compared with the binding of progesterone suggesting the 17,20-lyase is impaired by the C11-hydroxyl and keto moieties. bis-valerato-oxalato-1,2-diaminocyclohexaneplatinum aldo-keto reductase family 1 member C4 Homo sapiens
2 Docking of 11OHP4, 11KP4 and the 5alpha-reduced metabolites, 5alpha-pregnan-11beta-ol-3,20-dione (11OH-DHP4) and 5alpha-pregnan-3,11,20-trione (11K-DHP4) with human CYP17A1 showed minimal changes in the orientation of these C11-oxy C21 steroids in the active pocket when compared with the binding of progesterone suggesting the 17,20-lyase is impaired by the C11-hydroxyl and keto moieties. bis-valerato-oxalato-1,2-diaminocyclohexaneplatinum aldo-keto reductase family 1 member C4 Homo sapiens