Title : In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients.

Pub. Date : 2020 Sep

PMID : 32003035






1 Functional Relationships(s)
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1 PURPOSE: To generate a preclinical model of isocitrate dehydrogenase (IDH) mutant gliomas from glioma patients and design a MRS method to test the compatibility of 2-hydroxyglutarate (2HG) production between the preclinical model and patients. Isocitrates isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens