Title : The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.

Pub. Date : 2020 Mar 6

PMID : 32001619






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Consistent with this, the IKK inhibitor BAY11-7085 and dominant-negative mutant IkappaBalphaM inhibited NFkappaB activity and increased P-P53, P53, and P21/WAF1/CIP1 levels in a ROS-dependent manner. BAY 11-7085 cyclin dependent kinase inhibitor 1A Homo sapiens
2 Consistent with this, the IKK inhibitor BAY11-7085 and dominant-negative mutant IkappaBalphaM inhibited NFkappaB activity and increased P-P53, P53, and P21/WAF1/CIP1 levels in a ROS-dependent manner. BAY 11-7085 cyclin dependent kinase inhibitor 1A Homo sapiens
3 Consistent with this, the IKK inhibitor BAY11-7085 and dominant-negative mutant IkappaBalphaM inhibited NFkappaB activity and increased P-P53, P53, and P21/WAF1/CIP1 levels in a ROS-dependent manner. BAY 11-7085 cyclin dependent kinase inhibitor 1A Homo sapiens