Pub. Date : 2020 Jan 28
PMID : 31992334
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, CD44-positive HCC PDOs were obviously resistant to sorafenib, and sorafenib increased CD44 levels. | Sorafenib | CD44 molecule (Indian blood group) | Homo sapiens |
| 2 | Furthermore, CD44-positive HCC PDOs were obviously resistant to sorafenib, and sorafenib increased CD44 levels. | Sorafenib | CD44 molecule (Indian blood group) | Homo sapiens |
| 3 | Furthermore, CD44-positive HCC PDOs were obviously resistant to sorafenib, and sorafenib increased CD44 levels. | Sorafenib | CD44 molecule (Indian blood group) | Homo sapiens |
| 4 | In addition, there was a highly synergistic effect in vitro and in vivo on the suppression of cell viability and malignant properties when sorafenib and GANT61 were added to CD44-positive HCC PDOs and cell lines, respectively. | Sorafenib | CD44 molecule (Indian blood group) | Homo sapiens |
| 5 | Furthermore, the upregulation of CD44 and Hedgehog signaling induced by sorafenib was reversed by GANT61. | Sorafenib | CD44 molecule (Indian blood group) | Homo sapiens |
| 6 | CONCLUSIONS: GANT61 significantly suppressed Hedgehog signaling to reverse sorafenib resistance in CD44-positive HCC. | Sorafenib | CD44 molecule (Indian blood group) | Homo sapiens |
| 7 | The combination of sorafenib and Hedgehog signaling inhibitors might be effective in HCC patients with high CD44 levels as a personalized-medicine approach. | Sorafenib | CD44 molecule (Indian blood group) | Homo sapiens |