Title : Protamine stimulates platelet aggregation in vitro with activation of the fibrinogen receptor and alpha-granule release, but impairs secondary activation via ADP and thrombin receptors.

Pub. Date : 2021 Jan 2

PMID : 31992110






3 Functional Relationships(s)
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Protein Name
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1 When activated with ADP or TRAP protamine at 80 microg/mL reduced aggregation, from 73.8 +- 29.4 U to 46.9 +- 21.1 U (p < .001) with ADP and from 126.4 +- 16.1 U to 94.9 +- 23.7 U (p < .01) with TRAP. Insulin, Isophane TRAP Homo sapiens
2 When activated with ADP or TRAP protamine at 80 microg/mL reduced aggregation, from 73.8 +- 29.4 U to 46.9 +- 21.1 U (p < .001) with ADP and from 126.4 +- 16.1 U to 94.9 +- 23.7 U (p < .01) with TRAP. Insulin, Isophane TRAP Homo sapiens
3 When protamine was combined with ADP or TRAP, there was a concentration-dependent increase in the alpha-granule release. Insulin, Isophane TRAP Homo sapiens