Title : Structural-Dependent N,O-Donor Imine-Appended Cu(II)/Zn(II) Complexes: Synthesis, Spectral, and in Vitro Pharmacological Assessment.

Pub. Date : 2020 Jan 21

PMID : 31984281






2 Functional Relationships(s)
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1 On the basis of extended conjugation and planarity, L 1 complexes exhibited superior bioactivity with greater calculated DNA binding constant values, (K b) 2.9444 x 103 [(L 1 ) 2 Cu] and 2.2693 x 103 [(L 1 ) 2 Zn], as compared to L 2 complexes, 1.793 x 103 [(L 2 )Cu(H 2 O)] and 9.801 x 102 [(L 2 )Zn(H 2 O)]. Zinc L1 cell adhesion molecule Homo sapiens
2 On the basis of extended conjugation and planarity, L 1 complexes exhibited superior bioactivity with greater calculated DNA binding constant values, (K b) 2.9444 x 103 [(L 1 ) 2 Cu] and 2.2693 x 103 [(L 1 ) 2 Zn], as compared to L 2 complexes, 1.793 x 103 [(L 2 )Cu(H 2 O)] and 9.801 x 102 [(L 2 )Zn(H 2 O)]. Zinc L1 cell adhesion molecule Homo sapiens