Title : Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.

Pub. Date : 2020 Jan 21

PMID : 31984273






2 Functional Relationships(s)
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1 Herein, we report the synthesis of new substituted variants of Sondheimer dialkyne and their application in the stapling of p53-based diazido peptides to generate potent stapled peptide-based inhibitors of the oncogenic p53-MDM2 interaction. 2,8-diazidoadenosine 5'-triphosphate tumor protein p53 Homo sapiens
2 Herein, we report the synthesis of new substituted variants of Sondheimer dialkyne and their application in the stapling of p53-based diazido peptides to generate potent stapled peptide-based inhibitors of the oncogenic p53-MDM2 interaction. 2,8-diazidoadenosine 5'-triphosphate tumor protein p53 Homo sapiens