Title : Mutational effects of Cys113 on structural dynamics of Pin1.

Pub. Date : 2019

PMID : 31984197






1 Functional Relationships(s)
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1 According to various nuclear magnetic resonance experiments for mutants of C113 and molecular dynamics (MD) simulation of wild-type Pin1, the protonation sate of Sgamma of C113 regulates the hydrogen-bonding network of the dual-histidine motif (H59, H157) whose dynamics may affect substrate binding ability. histidine-pyridine-histidine-3 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens