Pub. Date : 2019
PMID : 31976328
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dihydroartemisinin Sensitizes Mutant p53 (R248Q)-Expressing Hepatocellular Carcinoma Cells to Doxorubicin by Inhibiting P-gp Expression. | artenimol | tumor protein p53 | Homo sapiens |
| 2 | However, combination of DHA and ADM treatment decreased cell viability and elevated cell apoptosis level in p53 (R248Q)-expressing Hep3B cells. | artenimol | tumor protein p53 | Homo sapiens |
| 3 | Molecular dynamics simulations showed that DHA had the potential to bind with mutant p53 (R248Q) protein. | artenimol | tumor protein p53 | Homo sapiens |
| 4 | Furthermore, DHA treatment decreased P-gp expression and inhibited phosphorylation levels of ERK1/2 and p65 in p53 (R248Q)-expressing Hep3B cells. | artenimol | tumor protein p53 | Homo sapiens |
| 5 | Finally, DHA treatment could significantly reduce ADM efflux in p53 (R248Q)-expressing cells. | artenimol | tumor protein p53 | Homo sapiens |
| 6 | Our results indicate that DHA could decrease P-gp expression via inhibiting the p53 (R248Q)-ERK1/2-NF-kappaB signaling pathway, which eventually confers sensitization of p53 (R248Q)-expressing HCC cells to ADM. Our study provides evidence for the potential application of DHA and ADM combination in treatment of mutant p53 (R248Q)-harbored HCC. | artenimol | tumor protein p53 | Homo sapiens |
| 7 | Our results indicate that DHA could decrease P-gp expression via inhibiting the p53 (R248Q)-ERK1/2-NF-kappaB signaling pathway, which eventually confers sensitization of p53 (R248Q)-expressing HCC cells to ADM. Our study provides evidence for the potential application of DHA and ADM combination in treatment of mutant p53 (R248Q)-harbored HCC. | artenimol | tumor protein p53 | Homo sapiens |
| 8 | Our results indicate that DHA could decrease P-gp expression via inhibiting the p53 (R248Q)-ERK1/2-NF-kappaB signaling pathway, which eventually confers sensitization of p53 (R248Q)-expressing HCC cells to ADM. Our study provides evidence for the potential application of DHA and ADM combination in treatment of mutant p53 (R248Q)-harbored HCC. | artenimol | tumor protein p53 | Homo sapiens |
| 9 | Our results indicate that DHA could decrease P-gp expression via inhibiting the p53 (R248Q)-ERK1/2-NF-kappaB signaling pathway, which eventually confers sensitization of p53 (R248Q)-expressing HCC cells to ADM. Our study provides evidence for the potential application of DHA and ADM combination in treatment of mutant p53 (R248Q)-harbored HCC. | artenimol | tumor protein p53 | Homo sapiens |