Pub. Date : 2020 Jan 23
PMID : 31974452
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Pifithrin-alpha alters p53 post-translational modifications pattern and differentially inhibits p53 target genes. | pifithrin | tumor protein p53 | Homo sapiens |
2 | Pifithrin-alpha alters p53 post-translational modifications pattern and differentially inhibits p53 target genes. | pifithrin | tumor protein p53 | Homo sapiens |
3 | Pifithrin-alpha (PFT-alpha) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity. | pifithrin | tumor protein p53 | Homo sapiens |
4 | Pifithrin-alpha (PFT-alpha) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity. | pifithrin | tumor protein p53 | Homo sapiens |
5 | PFT-alpha has also been described to display potent p53-independent activity in cells. | pifithrin | tumor protein p53 | Homo sapiens |
6 | PFT-alpha displayed a very limited effect on p53-dependent transcription upon its activation by Nutlin-3. | pifithrin | tumor protein p53 | Homo sapiens |
7 | Moreover, PFT-alpha inhibitory effect on transcription was highly dependent on the nature of the p53 target gene. | pifithrin | tumor protein p53 | Homo sapiens |
8 | PFT-alpha attenuated post-translational modifications of p53 without affecting total p53 protein level. | pifithrin | tumor protein p53 | Homo sapiens |
9 | Finally, we found that PFT-alpha can decrease the level of intracellular reactive oxygen species through activation of an aryl hydrocarbon receptor (AHR)-Nrf2 axis in a p53-independent manner. | pifithrin | tumor protein p53 | Homo sapiens |
10 | In conclusion, PFT-alpha inhibits only some aspects of p53 function, therefore it should be used with extreme caution to study p53-dependent processes. | pifithrin | tumor protein p53 | Homo sapiens |
11 | In conclusion, PFT-alpha inhibits only some aspects of p53 function, therefore it should be used with extreme caution to study p53-dependent processes. | pifithrin | tumor protein p53 | Homo sapiens |