Title : Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation.

Pub. Date : 2020 Feb 14

PMID : 31971218






2 Functional Relationships(s)
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1 Herein, we report the design and synthesis of a tetrazine-based disulfide rebridging reagent, which allows the site-selective installation of a tetrazine group into disulfide-containing peptides and proteins such as the hormone somatostatin (SST) and the antigen binding fragment (Fab) of human immunoglobulin G (IgG). Disulfides FA complementation group B Homo sapiens
2 Herein, we report the design and synthesis of a tetrazine-based disulfide rebridging reagent, which allows the site-selective installation of a tetrazine group into disulfide-containing peptides and proteins such as the hormone somatostatin (SST) and the antigen binding fragment (Fab) of human immunoglobulin G (IgG). Disulfides FA complementation group B Homo sapiens