Pub. Date : 2020 Mar
PMID : 31968217
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we discovered that chronic alcohol treatment increased editing of RNA of 5-HT2CR via up-regulating the expression of ADAR2, consequently reducing the release of ATP from astrocytes induced by 5-HT2CR agonist, MK212. | 6-chloro-2-(1-piperazinyl)pyrazine | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 2 | In this study, we discovered that chronic alcohol treatment increased editing of RNA of 5-HT2CR via up-regulating the expression of ADAR2, consequently reducing the release of ATP from astrocytes induced by 5-HT2CR agonist, MK212. | 6-chloro-2-(1-piperazinyl)pyrazine | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |
| 3 | The increased release of astroglial ATP by MK212 which was suppressed by chronic alcohol consumption, and reduction in ADAR2 activity eliminated the RNA editing of 5-HT2CR increased by alcohol in vitro and recovered the release of ATP from astrocytes induced by MK212. | 6-chloro-2-(1-piperazinyl)pyrazine | 5-hydroxytryptamine (serotonin) receptor 2C | Mus musculus |