Title : SPOP is essential for DNA-protein cross-link repair in prostate cancer cells: SPOP-dependent removal of topoisomerase 2A from the topoisomerase 2A-DNA cleavage complex.

Pub. Date : 2020 Mar 15

PMID : 31967940






2 Functional Relationships(s)
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1 The depletion of SPOP or overexpression of a prostate cancer-associated SPOP mutant, F133V, in androgen receptor-positive prostate cancer cells increased the amount of topoisomerase 2A (TOP2A) in the nuclei together with the increased amount of gammaH2AX, an indication of DNA breaks. Androgens DNA topoisomerase II alpha Homo sapiens
2 The depletion of SPOP or overexpression of a prostate cancer-associated SPOP mutant, F133V, in androgen receptor-positive prostate cancer cells increased the amount of topoisomerase 2A (TOP2A) in the nuclei together with the increased amount of gammaH2AX, an indication of DNA breaks. Androgens DNA topoisomerase II alpha Homo sapiens