Title : Feedback regulation of polyamine synthesis in Ehrlich ascites tumor cells. Analysis using nonmetabolizable derivatives of putrescine and spermine.

Pub. Date : 1988 Dec 9

PMID : 3196761






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Thus, addition of putrescine, spermidine or spermine to cells causes inhibition of ODC mRNA translation. Spermine ornithine decarboxylase, structural 1 Mus musculus
2 Therefore, it is conceivable that the inhibition of ODC synthesis observed in putrescine- and spermine-supplemented cells is instead an effect of spermidine. Spermine ornithine decarboxylase, structural 1 Mus musculus
3 Both analogs were found to inhibit the incorporation of [35S]methionine into ODC protein to approximately the same extent, suggesting that putrescine as well as spermine exert a negative feedback control of ODC mRNA translation in the cell. Spermine ornithine decarboxylase, structural 1 Mus musculus