Title : Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition.

Pub. Date : 2020 Jan

PMID : 31964274






4 Functional Relationships(s)
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Compound Name
Protein Name
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1 Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA-N-glycosylase (APNG) and methylguanine-DNA-methyltransferase (MGMT) efficiently mediate the repair of DNA damage caused by temozolomide, reducing treatment efficacy. temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens
2 Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA-N-glycosylase (APNG) and methylguanine-DNA-methyltransferase (MGMT) efficiently mediate the repair of DNA damage caused by temozolomide, reducing treatment efficacy. temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens
3 Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA-N-glycosylase (APNG) and methylguanine-DNA-methyltransferase (MGMT) efficiently mediate the repair of DNA damage caused by temozolomide, reducing treatment efficacy. temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens
4 Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-DNA-N-glycosylase (APNG) and methylguanine-DNA-methyltransferase (MGMT) efficiently mediate the repair of DNA damage caused by temozolomide, reducing treatment efficacy. temozolomide O-6-methylguanine-DNA methyltransferase Homo sapiens