Pub. Date : 2020 Mar
PMID : 31960518
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: An investigation at the protein level. | Trichloroacetic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA cycle are associated with IDH1 mut. | Trichloroacetic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | We observed significant changes in the enzyme abundance associated with aerobic glycolysis, glutamate metabolism, and the TCA cycle in IDH1 mut gliomas. | Trichloroacetic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | We conclude that in IDH1 mut glioma metabolism is rewired (increased input of lactate and glutamate) to preserve TCA-cycle activity in IDH1 mut gliomas. | Trichloroacetic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 5 | We conclude that in IDH1 mut glioma metabolism is rewired (increased input of lactate and glutamate) to preserve TCA-cycle activity in IDH1 mut gliomas. | Trichloroacetic Acid | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |