Title : Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway.

Pub. Date : 2020 Jan

PMID : 31957323






3 Functional Relationships(s)
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1 Further mechanistic study identified that celastrol regulated the PI3K/Akt signaling pathway, and the antitumor efficacy was likely due to the upregulation of PTEN, a negative regulator of PI3K/Akt. celastrol phosphatase and tensin homolog Mus musculus
2 Blockage of PTEN abolished the celastrol-induced PI3K/Akt signaling inhibition. celastrol phosphatase and tensin homolog Mus musculus
3 CONCLUSIONS: Overall, our study elucidated a mechanistic framework for the anti-CCA effects of celastrol via PTEN/PI3K/Akt pathway. celastrol phosphatase and tensin homolog Mus musculus