Pub. Date : 2020 Apr
PMID : 31954876
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1. | Prazosin | tensin 1 | Homo sapiens | ||
| 2 | Moreover, by RNA-seq analysis, we found that the expression of tensin 1 (TNS1) was down-regulated by prazosin, and down-regulation of TNS1 could inhibit cell viability of U937 and HL60 cells, as well as induced cell apoptosis. | Prazosin | tensin 1 | Homo sapiens | ||
| 3 | Moreover, by RNA-seq analysis, we found that the expression of tensin 1 (TNS1) was down-regulated by prazosin, and down-regulation of TNS1 could inhibit cell viability of U937 and HL60 cells, as well as induced cell apoptosis. | Prazosin | tensin 1 | Homo sapiens | ||
| 4 | Furthermore, up-regulation of TNS1 could reverse the effects of prazosin on viability and apoptosis in U937 and HL-60 cells, as well as the PI3K/Akt/mTOR signaling pathway. | Prazosin | tensin 1 | Homo sapiens | ||
| 5 | CONCLUSION: These results highlight an anti-cancer activity of prazosin on AML by inhibiting the PI3K/Akt/mTOR pathway and targeting TNS1. | Prazosin | tensin 1 | Homo sapiens | ||