Pub. Date : 2020 Jan 15
PMID : 31952230
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRalpha/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-alpha-Induced Lung Inflammation. | mevastatin | tumor necrosis factor | Homo sapiens |
| 2 | RESULTS: Upregulation of HO-1 by MVS attenuated the tumor necrosis factor (TNF)-alpha-stimulated ICAM-1 expression associated with THP-1 adhesion to HPAEpiCs. | mevastatin | tumor necrosis factor | Homo sapiens |
| 3 | CONCLUSIONS: MVS-induced HO-1 is, at least in part, mediated through a p47phox/Nox2/ROS-dependent activation of c-Src/PDGFRalpha/PI3K/Akt-regulated Nrf2/ARE axis and suppresses the TNF-alpha-mediated inflammatory responses in HPAEpiCs. | mevastatin | tumor necrosis factor | Homo sapiens |