Pub. Date : 2020 Jan 15
PMID : 31941883
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. | Iron | iron responsive element binding protein 2 | Homo sapiens |
| 2 | Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes functional iron deficiency in beta cells. | Iron | iron responsive element binding protein 2 | Homo sapiens |
| 3 | Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes functional iron deficiency in beta cells. | Iron | iron responsive element binding protein 2 | Homo sapiens |
| 4 | Iron normalizes ms2t6A37 and proinsulin lysine incorporation, restoring insulin content and secretion in Irp2-/- beta cells. | Iron | iron responsive element binding protein 2 | Homo sapiens |