Title : Arsenite-Induced Mitochondrial Superoxide Formation: Time and Concentration Requirements for the Effects of the Metalloid on the Endoplasmic Reticulum and Mitochondria.

Pub. Date : 2020 Apr

PMID : 31941719






2 Functional Relationships(s)
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1 The dramatic anticipation of, sensitization to, the effects of arsenite caused by the IP3R or RyR agonists was accompanied by a parallel significant genotoxic response in the absence of detectable mitochondrial dysfunction and cytotoxicity. Arsenites ryanodine receptor 1 Homo sapiens
2 Indeed, a brief exposure to nanomolar levels of arsenite produced maximal effects under conditions in which the [Ca2+]m was increased by IP3R or RyR agonists. Arsenites ryanodine receptor 1 Homo sapiens