Title : New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment.

Pub. Date : 2020 Feb 15

PMID : 31928863






1 Functional Relationships(s)
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1 TSA (Thermal Shift Assay) results indicated that 21e, 22a-c and 22e-g exhibited strong binding force against Hsp90N with DeltaTm > 3, meanwhile, MTT assay also revealed these compounds displayed potent anticancer activity with IC50 values below 25 muM against HepG2, HeLa and MDA-MB-231 cells lines. monooxyethylene trimethylolpropane tristearate heat shock protein 90 alpha family class A member 1 Homo sapiens