Pub. Date : 2020 Jan 2
PMID : 31919413
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GSK3beta is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ. | quinone | glycogen synthase kinase 3 alpha | Homo sapiens |
| 2 | Using the quinone DMNQ, a ROS generator, we demonstrate that GSK3beta is involved in the regulation of ROS-dependent necrosis. | quinone | glycogen synthase kinase 3 alpha | Homo sapiens |
| 3 | During the quinone-induced pro-necrotic stress, GSK3beta gradually accumulates into the nucleus, before the collapse of the mitochondrial membrane potential. | quinone | glycogen synthase kinase 3 alpha | Homo sapiens |
| 4 | In summary, GSK3beta by blunting the anti-oxidant response and particularly NQO1 and NQO2 expression, favors the appearance of necrosis in response to ROS, as generated by the quinone DMNQ. | quinone | glycogen synthase kinase 3 alpha | Homo sapiens |