Title : Ablation of PKM2 ameliorated ER stress-induced apoptosis and associated inflammation response in IL-1β-treated chondrocytes via blocking Rspo2-mediated Wnt/β-catenin signaling.

Pub. Date : 2020 Oct

PMID : 31916291






2 Functional Relationships(s)
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1 Furthermore, PKM2 silencing protected chondrocytes against IL-1beta-triggered inflammatory response, as reflected by the downregulated release of proinflammatory mediators, including tumor necrosis factor-alpha, IL-6, inducible nitric oxide synthase, cyclooxygenase-2, and prostaglandin E2, as well as decreased nitric oxide generation. Nitric Oxide interleukin 1 beta Rattus norvegicus
2 Furthermore, PKM2 silencing protected chondrocytes against IL-1beta-triggered inflammatory response, as reflected by the downregulated release of proinflammatory mediators, including tumor necrosis factor-alpha, IL-6, inducible nitric oxide synthase, cyclooxygenase-2, and prostaglandin E2, as well as decreased nitric oxide generation. Nitric Oxide interleukin 1 beta Rattus norvegicus