Title : Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter.

Pub. Date : 2020 Jan 6

PMID : 31905343






1 Functional Relationships(s)
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1 The combined treatment of aspirin and cisplatin suppressed the expression of the anti-apoptotic protein Bcl-2 and the EMT-related proteins, up-regulated the levels of the cleaved PARP and Bax, and blocked the PI3K/AKT and RAF-MEK-ERK signaling pathway. Cisplatin AKT serine/threonine kinase 1 Homo sapiens