Title : Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols.

Pub. Date : 2020 Feb 1

PMID : 31902650






1 Functional Relationships(s)
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1 While 25-hydroxycholesterol induces both HMGCR degradation and SREBP inhibition in a nonselective manner, lanosterol selectively induces HMGCR degradation. 25-hydroxycholesterol 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens