Pub. Date : 2020 Apr 1
PMID : 31900275
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: While having no detectable effect in MSH6 wild-type GBMs, PARPi selectively restored TMZ sensitivity in MSH6-deficient GBM cells. | temozolomide | mutS homolog 6 | Homo sapiens |
| 2 | This genotype-specific restoration of activity translated in vivo, where combination treatment of veliparib and TMZ showed potent suppression of tumor growth of MSH6-inactivated orthotopic xenografts, compared with TMZ monotherapy. | temozolomide | mutS homolog 6 | Homo sapiens |
| 3 | CONCLUSIONS: PARPi restoration of TMZ chemosensitivity in MSH6-inactivated glioma represents a promising strategy to overcome acquired chemoresistance caused by MMR deficiency. | temozolomide | mutS homolog 6 | Homo sapiens |